Ozone therapy: What Published Research Says
This page lists publications found on PubMed, the US National Library of Medicine database. We did not write or review these studies and the list is not a verdict on any treatment. Findings differ by study design, patient group and device or product. Nothing here is medical advice or a promise of results.
If you are comparing providers or thinking about ozone therapy, published research is a good place to start the conversation. Systematic reviews and meta-analyses combine many studies and are listed first, followed by randomized trials and other reviews. Open each record to read the authors' own summary and any stated limitations.
Recent peer-reviewed publications
- The effects of oxygen-ozone therapy in knee osteoarthritis: A systematic review. (J Back Musculoskelet Rehabil, 2025; Systematic Review): Read the article
- Use of ozone therapy in Implant Dentistry: a systematic review. (Oral Maxillofac Surg, 2024; Systematic Review): Read the article
- American Academy of Orthopaedic Surgeons Technology Overview Summary: Platelet-Rich Plasma (PRP) for Knee Osteoarthritis. (J Am Acad Orthop Surg, 2024; Systematic Review): Read the article
- Efficacy of ozone therapy for oral mucosa wound healing: a systematic review and meta-analysis. (Clin Oral Investig, 2024; Meta-Analysis): Read the article
- Ozone therapy as a treatment for diabetic foot ulcers: a systematic review and meta-analysis. (J Wound Care, 2024; Systematic Review): Read the article
- Effectiveness of adjunct therapy for the treatment of apical periodontitis: A systematic review and meta-analysis. (Int Endod J, 2023; Meta-Analysis): Read the article
- Ozone for the treatment of temporomandibular joint disorders: a systematic review and meta-analysis. (Med Gas Res, 2023; Meta-Analysis): Read the article
- A systematic review of ozone therapy for treating chronically refractory wounds and ulcers. (Int Wound J, 2022; Systematic Review): Read the article
Questions to bring to a licensed provider
- What does the research say about people like me, and what are its limits?
- Which risks and side effects are described, and how are they managed here?
- Who performs the treatment and under whose supervision?
- What happens if I am not happy with the outcome?
Browse the Blog and the service guides for plain-language explainers, and use MedSpa Listings to find clinics near you. Listing in the directory is not an endorsement.
Medical Disclaimer
The information on MedSpa Listings is for educational purposes only and is not medical advice. It does not create a provider-patient relationship. Always consult with a board-certified physician or qualified healthcare provider before undergoing any medical spa treatment. Individual results may vary. MedSpa Listings does not endorse any specific provider, treatment, or product.
Medspa Listings Team
Fact-CheckedHealth & Wellness Editorial Team
Fact-Checked Content
The Medspa Listings editorial team researches and fact-checks every article using peer-reviewed studies, FDA resources, and guidance from professional associations like the American Society of Plastic Surgeons (ASPS) and the American Academy of Dermatology (AAD). Our content is for informational purposes and does not replace professional medical advice.
Editorial & Medical Content Note
Articles on MedSpa Listings are intended for educational purposes and summarize treatment concepts, pricing ranges, and provider-selection considerations. Content is reviewed by the editorial team and updated over time as new information becomes available.
This information is not a substitute for individualized medical advice. Patients should consult qualified licensed providers before beginning any aesthetic or medical treatment plan.
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